diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index fbee593f7c2..e11493d1b44 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -61,6 +61,7 @@ jobs:
           "windows-py310-unittest-twisted25",
           "windows-py310-pluggy",
           "windows-py310-xdist",
+          "windows-py310-lowestdirect-onlymanaged",
           "windows-py311",
           "windows-py312",
           "windows-py313",
@@ -73,6 +74,7 @@ jobs:
           "ubuntu-py310-pluggy",
           "ubuntu-py310-freeze",
           "ubuntu-py310-xdist",
+          "ubuntu-py310-lowestdirect-onlymanaged",
           "ubuntu-py311",
           "ubuntu-py312",
           "ubuntu-py313-pexpect",
@@ -80,6 +82,7 @@ jobs:
           "ubuntu-pypy3-xdist",
 
           "macos-py310",
+          "macos-py310-lowestdirect-onlymanaged",
           "macos-py312",
           "macos-py313",
           "macos-py314",
@@ -119,6 +122,12 @@ jobs:
             os: windows-latest
             tox_env: "py310-xdist"
 
+          - name: "windows-py310-lowestdirect-onlymanaged"
+            python: "3.10"
+            os: windows-latest
+            tox_env: "py310-lowestdirect-onlymanaged"
+            use_uv: true
+
           - name: "windows-py311"
             python: "3.11"
             os: windows-latest
@@ -182,6 +191,12 @@ jobs:
             os: ubuntu-latest
             tox_env: "py310-xdist"
 
+          - name: "ubuntu-py310-lowestdirect-onlymanaged"
+            python: "3.10"
+            os: ubuntu-latest
+            tox_env: "py310-lowestdirect-onlymanaged"
+            use_uv: true
+
           - name: "ubuntu-py311"
             python: "3.11"
             os: ubuntu-latest
@@ -219,6 +234,13 @@ jobs:
             tox_env: "py310-xdist"
             xfail: true
 
+          - name: "macos-py310-lowestdirect-onlymanaged"
+            python: "3.10"
+            os: macos-latest
+            tox_env: "py310-lowestdirect-onlymanaged"
+            xfail: true
+            use_uv: true
+
           - name: "macos-py312"
             python: "3.12"
             os: macos-latest
@@ -273,6 +295,11 @@ jobs:
         python -m pip install --upgrade pip
         pip install tox coverage
 
+    - name: Set up uv
+      if: "matrix.use_uv"
+      shell: bash
+      run: pip install tox-uv
+
     - name: Test without coverage
       if: "! matrix.use_coverage"
       shell: bash
diff --git a/changelog/13177.packaging.rst b/changelog/13177.packaging.rst
new file mode 100644
index 00000000000..ef4d0c8ab0b
--- /dev/null
+++ b/changelog/13177.packaging.rst
@@ -0,0 +1,3 @@
+Raised minimal versions of ``exceptiongroup``, ``iniconfig`` and ``pygments`` following uv powered test runs using the ``lowest-direct`` resolution strategy.
+
+-- by :user:`sgaist`
diff --git a/pyproject.toml b/pyproject.toml
index f57d7e8e85b..2bc04f2cf90 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -47,21 +47,21 @@ dynamic = [
 ]
 dependencies = [
     "colorama>=0.4; sys_platform=='win32'",
-    "exceptiongroup>=1; python_version<'3.11'",
-    "iniconfig>=1.0.1",
+    "exceptiongroup>=1.1; python_version<'3.11'",
+    "iniconfig>=2",
     "packaging>=22",
     "pluggy>=1.5,<2",
-    "pygments>=2.7.2",
+    "pygments>=2.14",
     "tomli>=1; python_version<'3.11'",
 ]
 optional-dependencies.dev = [
-    "argcomplete",
-    "attrs>=19.2",
-    "hypothesis>=3.56",
-    "mock",
-    "requests",
-    "setuptools",
-    "xmlschema",
+    "argcomplete>=3.5",
+    "attrs>=21",
+    "hypothesis>=5",
+    "mock>=5",
+    "requests>=2.26",
+    "setuptools>=80",
+    "xmlschema>=3",
 ]
 urls.Changelog = "https://docs.pytest.org/en/stable/changelog.html"
 urls.Contact = "https://docs.pytest.org/en/stable/contact.html"
diff --git a/testing/acceptance_test.py b/testing/acceptance_test.py
index b9384008483..8ec0cddbf72 100644
--- a/testing/acceptance_test.py
+++ b/testing/acceptance_test.py
@@ -1642,12 +1642,23 @@ def test_fail_call():
     result = pytester.runpytest()
     assert result.ret == ExitCode.TESTS_FAILED
     result.assert_outcomes(failed=1, passed=1, errors=2)
-    result.stdout.fnmatch_lines(
-        [
-            "=* short test summary info =*",
-            "FAILED test_it.py::test_fail_call - StopIteration: 3",
-            "ERROR test_it.py::test_fail_setup - StopIteration: 1",
-            "ERROR test_it.py::test_fail_teardown - StopIteration: 2",
-            "=* 1 failed, 1 passed, 2 errors in * =*",
-        ]
-    )
+
+    # uv managed python versions do not raise the same exception with regard to
+    # StopIteration.
+    # See PEP-0479
+    runtime_errors = {
+        "FAILED test_it.py::test_fail_call - RuntimeError: generator raised StopIteration",
+        "ERROR test_it.py::test_fail_setup - RuntimeError: generator raised StopIteration",
+        "ERROR test_it.py::test_fail_teardown - RuntimeError: generator raised StopIte...",
+    }
+    got_runtime_errors = runtime_errors.issubset(result.outlines)
+
+    stopiteration_errors = {
+        "FAILED test_it.py::test_fail_call - StopIteration: 3",
+        "ERROR test_it.py::test_fail_setup - StopIteration: 1",
+        "ERROR test_it.py::test_fail_teardown - StopIteration: 2",
+    }
+
+    got_stopiteration_errors = stopiteration_errors.issubset(result.outlines)
+
+    assert got_runtime_errors or got_stopiteration_errors
diff --git a/tox-uv.ini b/tox-uv.ini
new file mode 100644
index 00000000000..386a270034a
--- /dev/null
+++ b/tox-uv.ini
@@ -0,0 +1,28 @@
+[tox]
+requires =
+    tox>=4
+    tox-uv>=1
+isolated_build = True
+distshare = {homedir}/.tox/uv-distshare
+envlist =
+    py310
+
+[testenv]
+description =
+    run the tests
+    under `{basepython}`
+uv_resolution = lowest-direct
+uv_python_preference = only-managed
+commands =
+    {env:_PYTEST_TOX_COVERAGE_RUN:} pytest {posargs:{env:_PYTEST_TOX_DEFAULT_POSARGS:}} --maxfail=1 --pdb
+passenv =
+    PYTEST_ADDOPTS
+    TERM
+    SETUPTOOLS_SCM_PRETEND_VERSION_FOR_PYTEST
+    CI
+setenv =
+    _PYTEST_TOX_DEFAULT_POSARGS={env:_PYTEST_TOX_POSARGS_DOCTESTING:} {env:_PYTEST_TOX_POSARGS_LSOF:} {env:_PYTEST_TOX_POSARGS_XDIST:} {env:_PYTEST_FILES:}
+
+extras = dev
+deps =
+    {env:_PYTEST_TOX_EXTRA_DEP:}
diff --git a/tox.ini b/tox.ini
index b6fcecc886a..a9eda9921dd 100644
--- a/tox.ini
+++ b/tox.ini
@@ -9,7 +9,7 @@ envlist =
     py313
     py314
     pypy3
-    py310-{pexpect,xdist,twisted24,twisted25,asynctest,numpy,pluggymain,pylib}
+    py310-{pexpect,xdist,twisted24,twisted25,asynctest,numpy,pluggymain,pylib,lowestdirect,onlymanaged}
     doctesting
     doctesting-coverage
     plugins
@@ -38,6 +38,8 @@ description =
     twisted25: against the unit test extras with twisted 25.0 or later
     asynctest: against the unit test extras with asynctest
     xdist: with pytest in parallel mode
+    lowestdirect: using lowest-direct resolution when running with uv
+    onlymanaged: using only managed python running with uv
     under `{basepython}`
     doctesting: including doctests
 commands =
@@ -79,6 +81,10 @@ setenv =
     lsof: _PYTEST_TOX_POSARGS_LSOF=--lsof
 
     xdist: _PYTEST_TOX_POSARGS_XDIST=-n auto
+uv_resolution =
+    lowestdirect: lowest-direct
+uv_python_preference =
+    onlymanaged: only-managed
 extras = dev
 deps =
     doctesting: PyYAML