diff --git a/pandas/_testing/asserters.py b/pandas/_testing/asserters.py
index 3f95997bb84f4..9701bd877ab3a 100644
--- a/pandas/_testing/asserters.py
+++ b/pandas/_testing/asserters.py
@@ -951,6 +951,10 @@ def assert_series_equal(
     >>> b = pd.Series([1, 2, 3, 4])
     >>> tm.assert_series_equal(a, b)
     """
+    if not check_dtype:
+        left = left.astype("object")
+        right = right.astype("object")
+
     __tracebackhide__ = True
     if (
         check_exact is lib.no_default
diff --git a/pandas/tests/util/test_assert_series_equal.py b/pandas/tests/util/test_assert_series_equal.py
index 8c9fff8e6ae2d..79b141a9393db 100644
--- a/pandas/tests/util/test_assert_series_equal.py
+++ b/pandas/tests/util/test_assert_series_equal.py
@@ -10,6 +10,16 @@
 import pandas._testing as tm
 
 
+def test_assert_frame_equal_na_different_dtype():
+    import pandas as pd
+    from pandas.testing import assert_frame_equal
+
+    df1 = pd.DataFrame({"x": pd.Series([pd.NA], dtype="Int32")})
+    df2 = pd.DataFrame({"x": pd.Series([pd.NA], dtype="object")})
+
+    assert_frame_equal(df1, df2, check_dtype=False)
+
+
 def _assert_series_equal_both(a, b, **kwargs):
     """
     Check that two Series equal.