diff --git a/.github/workflows/addlicense.yml b/.github/workflows/addlicense.yml
index 8d66691ff7..83e5b29ef4 100644
--- a/.github/workflows/addlicense.yml
+++ b/.github/workflows/addlicense.yml
@@ -39,7 +39,7 @@ jobs:
     permissions:
       contents: read
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
diff --git a/.github/workflows/benchmarks.yml b/.github/workflows/benchmarks.yml
index 513e467f29..a65695e7c4 100644
--- a/.github/workflows/benchmarks.yml
+++ b/.github/workflows/benchmarks.yml
@@ -38,7 +38,7 @@ jobs:
       BASE_SHA: ${{ github.event.pull_request.base.sha }}
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
         with:
           fetch-depth: 0
 
diff --git a/.github/workflows/build-ci-image.yml b/.github/workflows/build-ci-image.yml
index ab183f48a2..061233b6dd 100644
--- a/.github/workflows/build-ci-image.yml
+++ b/.github/workflows/build-ci-image.yml
@@ -43,7 +43,7 @@ jobs:
     name: Docker Build ${{ matrix.platform }}
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
         with:
           persist-credentials: false
           fetch-depth: 0
@@ -60,7 +60,7 @@ jobs:
 
       - name: Generate Docker Metadata (Tags and Labels)
         id: meta
-        uses: docker/metadata-action@c1e51972afc2121e065aed6d45c65596fe445f3f # 5.8.0
+        uses: docker/metadata-action@318604b99e75e41977312d83839a89be02ca4893 # 5.9.0
         with:
           images: ghcr.io/${{ steps.image-name.outputs.IMAGE_NAME }}
           flavor: |
@@ -139,7 +139,7 @@ jobs:
 
       - name: Generate Docker Metadata (Tags and Labels)
         id: meta
-        uses: docker/metadata-action@c1e51972afc2121e065aed6d45c65596fe445f3f # 5.8.0
+        uses: docker/metadata-action@318604b99e75e41977312d83839a89be02ca4893 # 5.9.0
         with:
           images: ghcr.io/${{ steps.image-name.outputs.IMAGE_NAME }}
           flavor: |
diff --git a/.github/workflows/deploy.yml b/.github/workflows/deploy.yml
index 8b469eaacb..af4739f2a3 100644
--- a/.github/workflows/deploy.yml
+++ b/.github/workflows/deploy.yml
@@ -69,14 +69,14 @@ jobs:
     runs-on: ${{ matrix.os }}
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
         with:
           persist-credentials: false
           fetch-depth: 0
 
       - name: Setup QEMU
         if: runner.os == 'Linux'
-        uses: docker/setup-qemu-action@29109295f81e9208d7d86ff1c6c12d2833863392 # 3.6.0
+        uses: docker/setup-qemu-action@c7c53464625b32c7a7e944ae62b3e17d2b600130 # 3.7.0
         with:
           platforms: arm64
 
@@ -109,7 +109,7 @@ jobs:
     runs-on: ubuntu-24.04
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
         with:
           persist-credentials: false
           fetch-depth: 0
diff --git a/.github/workflows/mega-linter.yml b/.github/workflows/mega-linter.yml
index 8f74866d43..0f869f3b58 100644
--- a/.github/workflows/mega-linter.yml
+++ b/.github/workflows/mega-linter.yml
@@ -45,7 +45,7 @@ jobs:
     steps:
       # Git Checkout
       - name: Checkout Code
-        uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+        uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
         with:
           token: ${{ secrets.PAT || secrets.GITHUB_TOKEN }}
           fetch-depth: 0 # Required for pushing commits to PRs
diff --git a/.github/workflows/tests.yml b/.github/workflows/tests.yml
index e9ef7b2d4e..9e47302bd4 100644
--- a/.github/workflows/tests.yml
+++ b/.github/workflows/tests.yml
@@ -93,7 +93,7 @@ jobs:
       - tests
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
       - uses: actions/setup-python@e797f83bcb11b83ae66e0230d6156d7c80228e7c # 6.0.0
         with:
           python-version: "3.13"
@@ -127,7 +127,7 @@ jobs:
       - tests
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
       - uses: actions/setup-python@e797f83bcb11b83ae66e0230d6156d7c80228e7c # 6.0.0
         with:
           python-version: "3.13"
@@ -166,7 +166,7 @@ jobs:
         --add-host=host.docker.internal:host-gateway
     timeout-minutes: 30
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -231,7 +231,7 @@ jobs:
         --add-host=host.docker.internal:host-gateway
     timeout-minutes: 30
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -294,14 +294,14 @@ jobs:
     runs-on: windows-2025
     timeout-minutes: 30
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
           git fetch --tags origin
 
       - name: Install uv
-        uses: astral-sh/setup-uv@85856786d1ce8acfbcc2f13a5f3fbd6b938f9f41 # 7.1.2
+        uses: astral-sh/setup-uv@5a7eac68fb9809dea845d802897dc5c723910fa3 # 7.1.3
 
       - name: Install Python
         run: |
@@ -363,14 +363,14 @@ jobs:
     runs-on: windows-11-arm
     timeout-minutes: 30
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
           git fetch --tags origin
 
       - name: Install uv
-        uses: astral-sh/setup-uv@85856786d1ce8acfbcc2f13a5f3fbd6b938f9f41 # 7.1.2
+        uses: astral-sh/setup-uv@5a7eac68fb9809dea845d802897dc5c723910fa3 # 7.1.3
 
       - name: Install Python
         run: |
@@ -443,7 +443,7 @@ jobs:
         --add-host=host.docker.internal:host-gateway
     timeout-minutes: 30
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -526,7 +526,7 @@ jobs:
           --health-retries 10
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -606,7 +606,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -687,7 +687,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -772,7 +772,7 @@ jobs:
         # from every being executed as bash commands.
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -837,7 +837,7 @@ jobs:
         --add-host=host.docker.internal:host-gateway
     timeout-minutes: 30
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -927,7 +927,7 @@ jobs:
           KAFKA_CFG_INTER_BROKER_LISTENER_NAME: L3
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1005,7 +1005,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1083,7 +1083,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1161,7 +1161,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1244,7 +1244,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1327,7 +1327,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1406,7 +1406,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1487,7 +1487,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1567,7 +1567,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1647,7 +1647,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1726,7 +1726,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1804,7 +1804,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -1923,7 +1923,7 @@ jobs:
           --add-host=host.docker.internal:host-gateway
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -2003,7 +2003,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
@@ -2081,7 +2081,7 @@ jobs:
           --health-retries 5
 
     steps:
-      - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+      - uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
 
       - name: Fetch git tags
         run: |
diff --git a/.github/workflows/trivy.yml b/.github/workflows/trivy.yml
index c373a38bb1..e4b0e38c9c 100644
--- a/.github/workflows/trivy.yml
+++ b/.github/workflows/trivy.yml
@@ -32,7 +32,7 @@ jobs:
     steps:
       # Git Checkout
       - name: Checkout Code
-        uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # 5.0.0
+        uses: actions/checkout@93cb6efe18208431cddfb8368fd83d5badbf9bfd # 5.0.1
         with:
           token: ${{ secrets.PAT || secrets.GITHUB_TOKEN }}
           fetch-depth: 0
@@ -61,6 +61,6 @@ jobs:
 
       - name: Upload Trivy scan results to GitHub Security tab
         if: ${{ github.event_name == 'schedule' }}
-        uses: github/codeql-action/upload-sarif@0499de31b99561a6d14a36a5f662c2a54f91beee # 4.31.2
+        uses: github/codeql-action/upload-sarif@014f16e7ab1402f30e7c3329d33797e7948572db # 4.31.3
         with:
           sarif_file: "trivy-results.sarif"
diff --git a/newrelic/api/asgi_application.py b/newrelic/api/asgi_application.py
index 669d3e6db5..6b9a31130e 100644
--- a/newrelic/api/asgi_application.py
+++ b/newrelic/api/asgi_application.py
@@ -132,10 +132,20 @@ async def send_inject_browser_agent(self, message):
 
         message_type = message["type"]
         if message_type == "http.response.start" and not self.initial_message:
-            headers = list(message.get("headers", ()))
+            # message["headers"] may be a generator, and consuming it via process_response will leave the original
+            # application with no headers. Fix this by preserving them in a list before consuming them.
+            if "headers" in message:
+                message["headers"] = headers = list(message["headers"])
+            else:
+                headers = []
+
+            # Check if we should insert the HTML snippet based on the headers.
+            # Currently if there are no headers this will always be False, but call the function
+            # anyway in case this logic changes in the future.
             if not self.should_insert_html(headers):
                 await self.abort()
                 return
+
             message["headers"] = headers
             self.initial_message = message
         elif message_type == "http.response.body" and self.initial_message:
@@ -232,7 +242,13 @@ async def send(self, event):
             finally:
                 self.__exit__(*sys.exc_info())
         elif event["type"] == "http.response.start":
-            self.process_response(event["status"], event.get("headers", ()))
+            # event["headers"] may be a generator, and consuming it via process_response will leave the original
+            # ASGI application with no headers. Fix this by preserving them in a list before consuming them.
+            if "headers" in event:
+                event["headers"] = headers = list(event["headers"])
+            else:
+                headers = []
+            self.process_response(event["status"], headers)
         return await self._send(event)
 
 
diff --git a/newrelic/api/transaction.py b/newrelic/api/transaction.py
index 8a5ba37a26..3356b05022 100644
--- a/newrelic/api/transaction.py
+++ b/newrelic/api/transaction.py
@@ -1084,8 +1084,8 @@ def _make_sampling_decision(self):
                 priority,
                 sampled,
                 full_granularity=True,
-                remote_parent_sampled_setting=self.settings.distributed_tracing.sampler.full_granularity.remote_parent_sampled,
-                remote_parent_not_sampled_setting=self.settings.distributed_tracing.sampler.full_granularity.remote_parent_not_sampled,
+                remote_parent_sampled_setting=self.settings.distributed_tracing.sampler.full_granularity._remote_parent_sampled,
+                remote_parent_not_sampled_setting=self.settings.distributed_tracing.sampler.full_granularity._remote_parent_not_sampled,
             )
             _logger.debug("Full granularity sampling decision was %s with priority=%s.", sampled, priority)
             if computed_sampled or not self.settings.distributed_tracing.sampler.partial_granularity.enabled:
@@ -1101,8 +1101,8 @@ def _make_sampling_decision(self):
                 priority,
                 sampled,
                 full_granularity=False,
-                remote_parent_sampled_setting=self.settings.distributed_tracing.sampler.partial_granularity.remote_parent_sampled,
-                remote_parent_not_sampled_setting=self.settings.distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled,
+                remote_parent_sampled_setting=self.settings.distributed_tracing.sampler.partial_granularity._remote_parent_sampled,
+                remote_parent_not_sampled_setting=self.settings.distributed_tracing.sampler.partial_granularity._remote_parent_not_sampled,
             )
             _logger.debug(
                 "Partial granularity sampling decision was %s with priority=%s.", self._sampled, self._priority
diff --git a/newrelic/config.py b/newrelic/config.py
index 41d118961f..c3944aa28c 100644
--- a/newrelic/config.py
+++ b/newrelic/config.py
@@ -337,7 +337,11 @@ def _process_dt_setting(section, option_p1, option_p2, getter):
         while True:
             if len(fields) == 1:
                 value = value1 or value2 or "default"
-                setattr(target, fields[0], value)
+                # Store the value at the underscored location so if option_p1 is
+                # distributed_tracing.sampler.full_granularity.remote_parent_sampled
+                # store it at location
+                # distributed_tracing.sampler.full_granularity._remote_parent_sampled
+                setattr(target, f"_{fields[0]}", value)
                 break
             target = getattr(target, fields[0])
             fields = fields[1].split(".", 1)
@@ -360,6 +364,90 @@ def _process_dt_setting(section, option_p1, option_p2, getter):
         _raise_configuration_error(section, option_p1)
 
 
+def _process_dt_hidden_setting(section, option, getter):
+    try:
+        # The type of a value is dictated by the getter
+        # function supplied.
+
+        value = getattr(_config_object, getter)(section, option)
+
+        # Now need to apply the option from the
+        # configuration file to the internal settings
+        # object. Walk the object path and assign it.
+
+        target = _settings
+        fields = option.split(".", 1)
+
+        while True:
+            if len(fields) == 1:
+                value = value or "default"
+                # Store the value at the underscored location so if option is
+                # distributed_tracing.sampler.full_granularity.remote_parent_sampled
+                # store it at location
+                # distributed_tracing.sampler.full_granularity._remote_parent_sampled
+                setattr(target, f"_{fields[0]}", value)
+                break
+            target = getattr(target, fields[0])
+            fields = fields[1].split(".", 1)
+
+        # Cache the configuration so can be dumped out to
+        # log file when whole main configuration has been
+        # processed. This ensures that the log file and log
+        # level entries have been set.
+
+        _cache_object.append((option, value))
+
+    except configparser.NoSectionError:
+        pass
+
+    except configparser.NoOptionError:
+        pass
+
+    except Exception:
+        _raise_configuration_error(section, option)
+
+
+def _process_dt_sampler_setting(section, option, getter):
+    try:
+        # The type of a value is dictated by the getter
+        # function supplied.
+
+        value = getattr(_config_object, getter)(section, option)
+
+        # Now need to apply the option from the
+        # configuration file to the internal settings
+        # object. Walk the object path and assign it.
+
+        target = _settings
+        fields = option.split(".", 1)
+
+        while True:
+            if len(fields) == 1:
+                setattr(target, f"{fields[0]}", value)
+                break
+            elif fields[0] in ("root", "remote_parent_sampled", "remote_parent_not_sampled"):
+                sampler = fields[1].split(".", 1)[0]
+                setattr(target, f"_{fields[0]}", sampler)
+            target = getattr(target, fields[0])
+            fields = fields[1].split(".", 1)
+
+        # Cache the configuration so can be dumped out to
+        # log file when whole main configuration has been
+        # processed. This ensures that the log file and log
+        # level entries have been set.
+
+        _cache_object.append((option, value))
+
+    except configparser.NoSectionError:
+        pass
+
+    except configparser.NoOptionError:
+        pass
+
+    except Exception:
+        _raise_configuration_error(section, option)
+
+
 # Processing of all the settings for specified section except
 # for log file and log level which are applied separately to
 # ensure they are set as soon as possible.
@@ -452,17 +540,37 @@ def _process_configuration(section):
         "distributed_tracing.sampler.remote_parent_sampled",
         "get",
     )
+    _process_dt_sampler_setting(
+        section, "distributed_tracing.sampler.full_granularity.remote_parent_sampled.adaptive.sampling_target", "getint"
+    )
     _process_dt_setting(
         section,
         "distributed_tracing.sampler.full_granularity.remote_parent_not_sampled",
         "distributed_tracing.sampler.remote_parent_not_sampled",
         "get",
     )
+    _process_dt_sampler_setting(
+        section,
+        "distributed_tracing.sampler.full_granularity.remote_parent_not_sampled.adaptive.sampling_target",
+        "getint",
+    )
     _process_setting(section, "distributed_tracing.sampler.full_granularity.enabled", "getboolean", None)
     _process_setting(section, "distributed_tracing.sampler.partial_granularity.enabled", "getboolean", None)
     _process_setting(section, "distributed_tracing.sampler.partial_granularity.type", "get", None)
-    _process_setting(section, "distributed_tracing.sampler.partial_granularity.remote_parent_sampled", "get", None)
-    _process_setting(section, "distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled", "get", None)
+    _process_dt_hidden_setting(section, "distributed_tracing.sampler.partial_granularity.remote_parent_sampled", "get")
+    _process_dt_sampler_setting(
+        section,
+        "distributed_tracing.sampler.partial_granularity.remote_parent_sampled.adaptive.sampling_target",
+        "getint",
+    )
+    _process_dt_hidden_setting(
+        section, "distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled", "get"
+    )
+    _process_dt_sampler_setting(
+        section,
+        "distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled.adaptive.sampling_target",
+        "getint",
+    )
     _process_setting(section, "span_events.enabled", "getboolean", None)
     _process_setting(section, "span_events.max_samples_stored", "getint", None)
     _process_setting(section, "span_events.attributes.enabled", "getboolean", None)
@@ -2141,6 +2249,10 @@ def _process_module_builtin_defaults():
         "asyncio.base_events", "newrelic.hooks.coroutines_asyncio", "instrument_asyncio_base_events"
     )
 
+    _process_module_definition("asyncio.events", "newrelic.hooks.coroutines_asyncio", "instrument_asyncio_events")
+
+    _process_module_definition("asyncio.runners", "newrelic.hooks.coroutines_asyncio", "instrument_asyncio_runners")
+
     _process_module_definition(
         "langchain_core.runnables.base",
         "newrelic.hooks.mlmodel_langchain",
@@ -2728,8 +2840,6 @@ def _process_module_builtin_defaults():
         "langchain_core.callbacks.manager", "newrelic.hooks.mlmodel_langchain", "instrument_langchain_callbacks_manager"
     )
 
-    _process_module_definition("asyncio.events", "newrelic.hooks.coroutines_asyncio", "instrument_asyncio_events")
-
     _process_module_definition("asgiref.sync", "newrelic.hooks.adapter_asgiref", "instrument_asgiref_sync")
 
     _process_module_definition(
diff --git a/newrelic/core/config.py b/newrelic/core/config.py
index fe5c9b5872..230e8067e5 100644
--- a/newrelic/core/config.py
+++ b/newrelic/core/config.py
@@ -338,10 +338,44 @@ class DistributedTracingSamplerSettings(Settings):
 
 
 class DistributedTracingSamplerFullGranularitySettings(Settings):
+    _remote_parent_sampled = "default"
+    _remote_parent_not_sampled = "default"
+
+
+class DistributedTracingSamplerFullGranularityRemoteParentSampledSettings:
+    pass
+
+
+class DistributedTracingSamplerFullGranularityRemoteParentSampledAdaptiveSettings:
+    pass
+
+
+class DistributedTracingSamplerFullGranularityRemoteParentNotSampledSettings:
+    pass
+
+
+class DistributedTracingSamplerFullGranularityRemoteParentNotSampledAdaptiveSettings:
     pass
 
 
 class DistributedTracingSamplerPartialGranularitySettings(Settings):
+    _remote_parent_sampled = "default"
+    _remote_parent_not_sampled = "default"
+
+
+class DistributedTracingSamplerPartialGranularityRemoteParentSampledSettings:
+    pass
+
+
+class DistributedTracingSamplerPartialGranularityRemoteParentSampledAdaptiveSettings:
+    pass
+
+
+class DistributedTracingSamplerPartialGranularityRemoteParentNotSampledSettings:
+    pass
+
+
+class DistributedTracingSamplerPartialGranularityRemoteParentNotSampledAdaptiveSettings:
     pass
 
 
@@ -516,7 +550,31 @@ class EventHarvestConfigHarvestLimitSettings(Settings):
 _settings.distributed_tracing = DistributedTracingSettings()
 _settings.distributed_tracing.sampler = DistributedTracingSamplerSettings()
 _settings.distributed_tracing.sampler.full_granularity = DistributedTracingSamplerFullGranularitySettings()
+_settings.distributed_tracing.sampler.full_granularity.remote_parent_sampled = (
+    DistributedTracingSamplerFullGranularityRemoteParentSampledSettings()
+)
+_settings.distributed_tracing.sampler.full_granularity.remote_parent_sampled.adaptive = (
+    DistributedTracingSamplerFullGranularityRemoteParentSampledAdaptiveSettings()
+)
+_settings.distributed_tracing.sampler.full_granularity.remote_parent_not_sampled = (
+    DistributedTracingSamplerFullGranularityRemoteParentNotSampledSettings()
+)
+_settings.distributed_tracing.sampler.full_granularity.remote_parent_not_sampled.adaptive = (
+    DistributedTracingSamplerFullGranularityRemoteParentNotSampledAdaptiveSettings()
+)
 _settings.distributed_tracing.sampler.partial_granularity = DistributedTracingSamplerPartialGranularitySettings()
+_settings.distributed_tracing.sampler.partial_granularity.remote_parent_sampled = (
+    DistributedTracingSamplerPartialGranularityRemoteParentSampledSettings()
+)
+_settings.distributed_tracing.sampler.partial_granularity.remote_parent_sampled.adaptive = (
+    DistributedTracingSamplerPartialGranularityRemoteParentSampledAdaptiveSettings()
+)
+_settings.distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled = (
+    DistributedTracingSamplerPartialGranularityRemoteParentNotSampledSettings()
+)
+_settings.distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled.adaptive = (
+    DistributedTracingSamplerPartialGranularityRemoteParentNotSampledAdaptiveSettings()
+)
 _settings.error_collector = ErrorCollectorSettings()
 _settings.error_collector.attributes = ErrorCollectorAttributesSettings()
 _settings.event_harvest_config = EventHarvestConfigSettings()
@@ -561,6 +619,8 @@ class EventHarvestConfigHarvestLimitSettings(Settings):
 def _environ_as_int(name, default=0):
     val = os.environ.get(name, default)
     try:
+        if default is None and val is None:
+            return None
         return int(val)
     except ValueError:
         return default
@@ -858,23 +918,70 @@ def default_otlp_host(host):
 _settings.distributed_tracing.sampler.full_granularity.enabled = _environ_as_bool(
     "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_ENABLED", default=True
 )
-_settings.distributed_tracing.sampler.full_granularity.remote_parent_sampled = os.environ.get(
-    "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_SAMPLED", None
-) or os.environ.get("NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_REMOTE_PARENT_SAMPLED", "default")
-_settings.distributed_tracing.sampler.full_granularity.remote_parent_not_sampled = os.environ.get(
-    "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED", None
-) or os.environ.get("NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_REMOTE_PARENT_NOT_SAMPLED", "default")
+_settings.distributed_tracing.sampler.full_granularity._remote_parent_sampled = (
+    (
+        "adaptive"
+        if os.environ.get(
+            "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_SAMPLED_ADAPTIVE_SAMPLING_TARGET",
+            None,
+        )
+        else None
+    )
+    or os.environ.get("NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_SAMPLED", None)
+    or os.environ.get("NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_REMOTE_PARENT_SAMPLED", "default")
+)
+_settings.distributed_tracing.sampler.full_granularity.remote_parent_sampled.adaptive.sampling_target = _environ_as_int(
+    "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_SAMPLED_ADAPTIVE_SAMPLING_TARGET", None
+)
+_settings.distributed_tracing.sampler.full_granularity._remote_parent_not_sampled = (
+    (
+        "adaptive"
+        if os.environ.get(
+            "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED_ADAPTIVE_SAMPLING_TARGET",
+            None,
+        )
+        else None
+    )
+    or os.environ.get("NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED", None)
+    or os.environ.get("NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_REMOTE_PARENT_NOT_SAMPLED", "default")
+)
+_settings.distributed_tracing.sampler.full_granularity.remote_parent_not_sampled.adaptive.sampling_target = (
+    _environ_as_int(
+        "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED_ADAPTIVE_SAMPLING_TARGET",
+        None,
+    )
+)
 _settings.distributed_tracing.sampler.partial_granularity.enabled = _environ_as_bool(
     "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_ENABLED", default=False
 )
 _settings.distributed_tracing.sampler.partial_granularity.type = os.environ.get(
     "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_TYPE", "essential"
 )
-_settings.distributed_tracing.sampler.partial_granularity.remote_parent_sampled = os.environ.get(
-    "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_SAMPLED", "default"
+_settings.distributed_tracing.sampler.partial_granularity._remote_parent_sampled = (
+    "adaptive"
+    if os.environ.get(
+        "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_SAMPLED_ADAPTIVE_SAMPLING_TARGET", None
+    )
+    else None
+) or os.environ.get("NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_SAMPLED", "default")
+_settings.distributed_tracing.sampler.partial_granularity.remote_parent_sampled.adaptive.sampling_target = (
+    _environ_as_int(
+        "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_SAMPLED_ADAPTIVE_SAMPLING_TARGET", None
+    )
 )
-_settings.distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled = os.environ.get(
-    "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED", "default"
+_settings.distributed_tracing.sampler.partial_granularity._remote_parent_not_sampled = (
+    "adaptive"
+    if os.environ.get(
+        "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED_ADAPTIVE_SAMPLING_TARGET",
+        None,
+    )
+    else None
+) or os.environ.get("NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED", "default")
+_settings.distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled.adaptive.sampling_target = (
+    _environ_as_int(
+        "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED_ADAPTIVE_SAMPLING_TARGET",
+        None,
+    )
 )
 _settings.distributed_tracing.exclude_newrelic_header = False
 _settings.span_events.enabled = _environ_as_bool("NEW_RELIC_SPAN_EVENTS_ENABLED", default=True)
diff --git a/newrelic/core/samplers/sampler_proxy.py b/newrelic/core/samplers/sampler_proxy.py
index 2e8b7cf87f..70cb706267 100644
--- a/newrelic/core/samplers/sampler_proxy.py
+++ b/newrelic/core/samplers/sampler_proxy.py
@@ -21,10 +21,41 @@ def __init__(self, settings):
         else:
             sampling_target_period = settings.sampling_target_period_in_seconds
         adaptive_sampler = AdaptiveSampler(settings.sampling_target, sampling_target_period)
-        self._samplers = [adaptive_sampler]
+        self._samplers = {"global": adaptive_sampler}
+        # Add adaptive sampler instances for each config section if configured.
+        self.add_adaptive_sampler(
+            (True, 1),
+            settings.distributed_tracing.sampler.full_granularity.remote_parent_sampled.adaptive.sampling_target,
+            sampling_target_period,
+        )
+        self.add_adaptive_sampler(
+            (True, 2),
+            settings.distributed_tracing.sampler.full_granularity.remote_parent_not_sampled.adaptive.sampling_target,
+            sampling_target_period,
+        )
+        self.add_adaptive_sampler(
+            (False, 1),
+            settings.distributed_tracing.sampler.partial_granularity.remote_parent_sampled.adaptive.sampling_target,
+            sampling_target_period,
+        )
+        self.add_adaptive_sampler(
+            (False, 2),
+            settings.distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled.adaptive.sampling_target,
+            sampling_target_period,
+        )
+
+    def add_adaptive_sampler(self, key, sampling_target, sampling_target_period):
+        """
+        Add an adaptive sampler instance to self._samplers if the sampling_target is specified.
+        """
+        if sampling_target:
+            adaptive_sampler = AdaptiveSampler(sampling_target, sampling_target_period)
+            self._samplers[key] = adaptive_sampler
 
     def get_sampler(self, full_granularity, section):
-        return self._samplers[0]
+        # Return the sampler instance for the given config section.
+        # If no instance is present, return the global adaptive sampler instance instead.
+        return self._samplers.get((full_granularity, section)) or self._samplers["global"]
 
     def compute_sampled(self, full_granularity, section, *args, **kwargs):
         """
diff --git a/newrelic/hooks/coroutines_asyncio.py b/newrelic/hooks/coroutines_asyncio.py
index 41fc776595..6f862d52dd 100644
--- a/newrelic/hooks/coroutines_asyncio.py
+++ b/newrelic/hooks/coroutines_asyncio.py
@@ -16,36 +16,73 @@
 from newrelic.core.trace_cache import trace_cache
 
 
-def remove_from_cache(task):
+def remove_from_cache_callback(task):
     cache = trace_cache()
     cache.task_stop(task)
 
 
-def propagate_task_context(task):
+def wrap_create_task(task):
     trace_cache().task_start(task)
-    task.add_done_callback(remove_from_cache)
+    task.add_done_callback(remove_from_cache_callback)
     return task
 
 
-def _bind_loop(loop, *args, **kwargs):
+def _instrument_event_loop(loop):
+    if loop and hasattr(loop, "create_task") and not hasattr(loop.create_task, "__wrapped__"):
+        wrap_out_function(loop, "create_task", wrap_create_task)
+
+
+def _bind_set_event_loop(loop, *args, **kwargs):
     return loop
 
 
-def wrap_create_task(wrapped, instance, args, kwargs):
-    loop = _bind_loop(*args, **kwargs)
+def wrap_set_event_loop(wrapped, instance, args, kwargs):
+    loop = _bind_set_event_loop(*args, **kwargs)
 
-    if loop and not hasattr(loop.create_task, "__wrapped__"):
-        wrap_out_function(loop, "create_task", propagate_task_context)
+    _instrument_event_loop(loop)
 
     return wrapped(*args, **kwargs)
 
 
+def wrap__lazy_init(wrapped, instance, args, kwargs):
+    result = wrapped(*args, **kwargs)
+    # This logic can be used for uvloop, but should
+    # work for any valid custom loop factory.
+
+    # A custom loop_factory will be used to create
+    # a new event loop instance.  It will then run
+    # the main() coroutine on this event loop.  Once
+    # this coroutine is complete, the event loop will
+    # be stopped and closed.
+
+    # The new loop that is created and set as the
+    # running loop of the duration of the run() call.
+    # When the coroutine starts, it runs in the context
+    # that was active when run() was called.  Any tasks
+    # created within this coroutine on this new event
+    # loop will inherit that context.
+
+    # Note: The loop created by loop_factory is never
+    # set as the global current loop for the thread,
+    # even while it is running.
+    loop = instance._loop
+    _instrument_event_loop(loop)
+
+    return result
+
+
 def instrument_asyncio_base_events(module):
-    wrap_out_function(module, "BaseEventLoop.create_task", propagate_task_context)
+    wrap_out_function(module, "BaseEventLoop.create_task", wrap_create_task)
 
 
 def instrument_asyncio_events(module):
     if hasattr(module, "_BaseDefaultEventLoopPolicy"):  # Python >= 3.14
-        wrap_function_wrapper(module, "_BaseDefaultEventLoopPolicy.set_event_loop", wrap_create_task)
-    else:  # Python <= 3.13
-        wrap_function_wrapper(module, "BaseDefaultEventLoopPolicy.set_event_loop", wrap_create_task)
+        wrap_function_wrapper(module, "_BaseDefaultEventLoopPolicy.set_event_loop", wrap_set_event_loop)
+    elif hasattr(module, "BaseDefaultEventLoopPolicy"):  # Python <= 3.13
+        wrap_function_wrapper(module, "BaseDefaultEventLoopPolicy.set_event_loop", wrap_set_event_loop)
+
+
+# For Python >= 3.11
+def instrument_asyncio_runners(module):
+    if hasattr(module, "Runner") and hasattr(module.Runner, "_lazy_init"):
+        wrap_function_wrapper(module, "Runner._lazy_init", wrap__lazy_init)
diff --git a/newrelic/hooks/framework_sanic.py b/newrelic/hooks/framework_sanic.py
index 14077eb6d9..74d8ab678e 100644
--- a/newrelic/hooks/framework_sanic.py
+++ b/newrelic/hooks/framework_sanic.py
@@ -183,7 +183,7 @@ async def _nr_sanic_response_send(wrapped, instance, args, kwargs):
     transaction = current_transaction()
     result = wrapped(*args, **kwargs)
     if isawaitable(result):
-        await result
+        result = await result
 
     if transaction is None:
         return result
diff --git a/tests/adapter_uvicorn/test_uvicorn.py b/tests/adapter_uvicorn/test_uvicorn.py
index 0084be3e46..d5db2d6ca6 100644
--- a/tests/adapter_uvicorn/test_uvicorn.py
+++ b/tests/adapter_uvicorn/test_uvicorn.py
@@ -56,8 +56,8 @@ def app(request):
     return request.param
 
 
-@pytest.fixture
-def port(app):
+@pytest.fixture(params=["asyncio", "uvloop", "none"], ids=["asyncio", "uvloop", "none"])
+def port(app, request):
     port = get_open_port()
 
     loops = []
@@ -72,7 +72,7 @@ def on_tick_sync():
         async def on_tick():
             on_tick_sync()
 
-        config = Config(app, host="127.0.0.1", port=port, loop="asyncio")
+        config = Config(app, host="127.0.0.1", port=port, loop=request.param)
         config.callback_notify = on_tick
         config.log_config = {"version": 1}
         config.disable_lifespan = True
diff --git a/tests/agent_features/test_agent_control_health_check.py b/tests/agent_features/test_agent_control_health_check.py
index e12f3a07f0..84058a1b28 100644
--- a/tests/agent_features/test_agent_control_health_check.py
+++ b/tests/agent_features/test_agent_control_health_check.py
@@ -38,7 +38,7 @@ def get_health_file_contents(tmp_path):
         return contents
 
 
-@pytest.fixture(scope="module", autouse=True)
+@pytest.fixture(autouse=True)
 def restore_settings_fixture():
     # Backup settings from before this test file runs
     original_settings = global_settings()
@@ -51,6 +51,10 @@ def restore_settings_fixture():
     original_settings.__dict__.clear()
     original_settings.__dict__.update(backup)
 
+    # Re-initialize the agent to restore the settings
+    _reset_configuration_done()
+    initialize()
+
 
 @pytest.mark.parametrize("file_uri", ["", "file://", "/test/dir", "foo:/test/dir"])
 def test_invalid_file_directory_supplied(monkeypatch, file_uri):
@@ -155,10 +159,18 @@ def test_no_override_on_unhealthy_shutdown(monkeypatch, tmp_path):
 
 
 def test_health_check_running_threads(monkeypatch, tmp_path):
-    running_threads = threading.enumerate()
-    # Only the main thread should be running since not agent control env vars are set
-    assert len(running_threads) == 1
+    # If the Activate-Session thread is still active, give it time to close before we proceed
+    timeout = 30.0
+    while len(threading.enumerate()) != 1 and timeout > 0:
+        time.sleep(0.1)
+        timeout -= 0.1
 
+    # Only the main thread should be running since no agent control env vars are set
+    assert len(threading.enumerate()) == 1, (
+        f"Expected only the main thread to be running before the test starts. Got: {threading.enumerate()}"
+    )
+
+    # Setup expected env vars to run agent control health check
     monkeypatch.setenv("NEW_RELIC_AGENT_CONTROL_ENABLED", "True")
     file_path = tmp_path.as_uri()
     monkeypatch.setenv("NEW_RELIC_AGENT_CONTROL_HEALTH_DELIVERY_LOCATION", file_path)
@@ -180,6 +192,7 @@ def test_proxy_error_status(monkeypatch, tmp_path):
     file_path = tmp_path.as_uri()
     monkeypatch.setenv("NEW_RELIC_AGENT_CONTROL_HEALTH_DELIVERY_LOCATION", file_path)
 
+    # Re-initialize the agent to allow the health check thread to start
     _reset_configuration_done()
     initialize()
 
@@ -209,6 +222,7 @@ def test_multiple_activations_running_threads(monkeypatch, tmp_path):
     file_path = tmp_path.as_uri()
     monkeypatch.setenv("NEW_RELIC_AGENT_CONTROL_HEALTH_DELIVERY_LOCATION", file_path)
 
+    # Re-initialize the agent to allow the health check thread to start and assert that it did
     _reset_configuration_done()
     initialize()
 
diff --git a/tests/agent_features/test_asgi_transaction.py b/tests/agent_features/test_asgi_transaction.py
index e70ec95901..ac774689bd 100644
--- a/tests/agent_features/test_asgi_transaction.py
+++ b/tests/agent_features/test_asgi_transaction.py
@@ -19,6 +19,7 @@
 from testing_support.fixtures import override_application_settings
 from testing_support.sample_asgi_applications import (
     AppWithDescriptor,
+    asgi_application_generator_headers,
     simple_app_v2,
     simple_app_v2_init_exc,
     simple_app_v2_raw,
@@ -37,6 +38,7 @@
 simple_app_v3_wrapped = AsgiTest(simple_app_v3)
 simple_app_v2_wrapped = AsgiTest(simple_app_v2)
 simple_app_v2_init_exc = AsgiTest(simple_app_v2_init_exc)
+asgi_application_generator_headers = AsgiTest(asgi_application_generator_headers)
 
 
 # Test naming scheme logic and ASGIApplicationWrapper for a single callable
@@ -85,6 +87,28 @@ def test_double_callable_raw():
     assert response.body == b""
 
 
+# Ensure headers object is preserved
+@pytest.mark.parametrize("browser_monitoring", [True, False])
+@validate_transaction_metrics(name="", group="Uri")
+def test_generator_headers(browser_monitoring):
+    """
+    Both ASGIApplicationWrapper and ASGIBrowserMiddleware can cause headers to be lost if generators are
+    not handled properly.
+
+    Ensure neither destroys headers by testing with and without the ASGIBrowserMiddleware, to make sure whichever
+    receives headers first properly preserves them in a list.
+    """
+
+    @override_application_settings({"browser_monitoring.enabled": browser_monitoring})
+    def _test():
+        response = asgi_application_generator_headers.make_request("GET", "/")
+        assert response.status == 200
+        assert response.headers == {"x-my-header": "myvalue"}
+        assert response.body == b""
+
+    _test()
+
+
 # Test asgi_application decorator with parameters passed in on a single callable
 @pytest.mark.parametrize("name, group", ((None, "group"), ("name", "group"), ("", "group")))
 def test_asgi_application_decorator_single_callable(name, group):
diff --git a/tests/agent_features/test_distributed_tracing.py b/tests/agent_features/test_distributed_tracing.py
index 33433ff7c9..0a64a4e97a 100644
--- a/tests/agent_features/test_distributed_tracing.py
+++ b/tests/agent_features/test_distributed_tracing.py
@@ -26,6 +26,7 @@
 from testing_support.validators.validate_transaction_event_attributes import validate_transaction_event_attributes
 from testing_support.validators.validate_transaction_metrics import validate_transaction_metrics
 
+from newrelic.api.application import application_instance
 from newrelic.api.function_trace import function_trace
 from newrelic.common.object_wrapper import function_wrapper, transient_function_wrapper
 
@@ -586,8 +587,8 @@ def test_distributed_trace_remote_parent_sampling_decision_full_granularity(
     test_settings = _override_settings.copy()
     test_settings.update(
         {
-            "distributed_tracing.sampler.full_granularity.remote_parent_sampled": remote_parent_sampled_setting,
-            "distributed_tracing.sampler.full_granularity.remote_parent_not_sampled": remote_parent_not_sampled_setting,
+            "distributed_tracing.sampler.full_granularity._remote_parent_sampled": remote_parent_sampled_setting,
+            "distributed_tracing.sampler.full_granularity._remote_parent_not_sampled": remote_parent_not_sampled_setting,
             "span_events.enabled": True,
         }
     )
@@ -677,8 +678,8 @@ def test_distributed_trace_remote_parent_sampling_decision_partial_granularity(
         {
             "distributed_tracing.sampler.full_granularity.enabled": False,
             "distributed_tracing.sampler.partial_granularity.enabled": True,
-            "distributed_tracing.sampler.partial_granularity.remote_parent_sampled": remote_parent_sampled_setting,
-            "distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled": remote_parent_not_sampled_setting,
+            "distributed_tracing.sampler.partial_granularity._remote_parent_sampled": remote_parent_sampled_setting,
+            "distributed_tracing.sampler.partial_granularity._remote_parent_not_sampled": remote_parent_not_sampled_setting,
             "span_events.enabled": True,
         }
     )
@@ -745,8 +746,8 @@ def test_distributed_trace_remote_parent_sampling_decision_between_full_and_part
         {
             "distributed_tracing.sampler.full_granularity.enabled": full_granularity_enabled,
             "distributed_tracing.sampler.partial_granularity.enabled": partial_granularity_enabled,
-            "distributed_tracing.sampler.full_granularity.remote_parent_sampled": full_granularity_remote_parent_sampled_setting,
-            "distributed_tracing.sampler.partial_granularity.remote_parent_sampled": partial_granularity_remote_parent_sampled_setting,
+            "distributed_tracing.sampler.full_granularity._remote_parent_sampled": full_granularity_remote_parent_sampled_setting,
+            "distributed_tracing.sampler.partial_granularity._remote_parent_sampled": partial_granularity_remote_parent_sampled_setting,
             "span_events.enabled": True,
         }
     )
@@ -815,7 +816,7 @@ def _test():
             "distributed_tracing.sampler.full_granularity.enabled": False,
             "distributed_tracing.sampler.partial_granularity.enabled": True,
             "distributed_tracing.sampler.partial_granularity.type": "compact",
-            "distributed_tracing.sampler.partial_granularity.remote_parent_sampled": "always_on",
+            "distributed_tracing.sampler.partial_granularity._remote_parent_sampled": "always_on",
             "span_events.enabled": True,
         }
     )(_test)
@@ -868,7 +869,7 @@ def _test():
             "distributed_tracing.sampler.full_granularity.enabled": False,
             "distributed_tracing.sampler.partial_granularity.enabled": True,
             "distributed_tracing.sampler.partial_granularity.type": "compact",
-            "distributed_tracing.sampler.partial_granularity.remote_parent_sampled": "always_on",
+            "distributed_tracing.sampler.partial_granularity._remote_parent_sampled": "always_on",
             "span_events.enabled": True,
         }
     )(_test)
@@ -918,7 +919,7 @@ def _test():
             "distributed_tracing.sampler.full_granularity.enabled": False,
             "distributed_tracing.sampler.partial_granularity.enabled": True,
             "distributed_tracing.sampler.partial_granularity.type": "compact",
-            "distributed_tracing.sampler.partial_granularity.remote_parent_sampled": "always_on",
+            "distributed_tracing.sampler.partial_granularity._remote_parent_sampled": "always_on",
             "span_events.enabled": True,
         }
     )(_test)
@@ -972,7 +973,7 @@ def _test():
             "distributed_tracing.sampler.full_granularity.enabled": False,
             "distributed_tracing.sampler.partial_granularity.enabled": True,
             "distributed_tracing.sampler.partial_granularity.type": "reduced",
-            "distributed_tracing.sampler.partial_granularity.remote_parent_sampled": "always_on",
+            "distributed_tracing.sampler.partial_granularity._remote_parent_sampled": "always_on",
             "span_events.enabled": True,
         }
     )(_test)
@@ -1026,9 +1027,118 @@ def _test():
             "distributed_tracing.sampler.full_granularity.enabled": False,
             "distributed_tracing.sampler.partial_granularity.enabled": True,
             "distributed_tracing.sampler.partial_granularity.type": "essential",
-            "distributed_tracing.sampler.partial_granularity.remote_parent_sampled": "always_on",
+            "distributed_tracing.sampler.partial_granularity._remote_parent_sampled": "always_on",
             "span_events.enabled": True,
         }
     )(_test)
 
     _test()
+
+
+@pytest.mark.parametrize(
+    "dt_settings,dt_headers,expected_sampling_instance_called,expected_adaptive_computed_count,expected_adaptive_sampled_count,expected_adaptive_sampling_target",
+    (
+        (
+            {
+                "distributed_tracing.sampler.full_granularity.enabled": False,
+                "distributed_tracing.sampler.partial_granularity.enabled": True,
+                "distributed_tracing.sampler.partial_granularity._remote_parent_sampled": "default",
+                "distributed_tracing.sampler.partial_granularity.remote_parent_sampled.adaptive.sampling_target": 5,
+                "distributed_tracing.sampler.partial_granularity._remote_parent_not_sampled": "default",
+                "distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled.adaptive.sampling_target": 6,
+            },
+            {"traceparent": "00-0af7651916cd43dd8448eb211c80319c-00f067aa0ba902b7-01"},
+            (False, 1),
+            1,
+            1,
+            5,
+        ),
+        (
+            {
+                "distributed_tracing.sampler.full_granularity.enabled": False,
+                "distributed_tracing.sampler.partial_granularity.enabled": True,
+                "distributed_tracing.sampler.partial_granularity._remote_parent_sampled": "default",
+                "distributed_tracing.sampler.partial_granularity.remote_parent_sampled.adaptive.sampling_target": 5,
+                "distributed_tracing.sampler.partial_granularity._remote_parent_not_sampled": "default",
+                "distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled.adaptive.sampling_target": 6,
+            },
+            {"traceparent": "00-0af7651916cd43dd8448eb211c80319c-00f067aa0ba902b7-00"},
+            (False, 2),
+            1,
+            1,
+            6,
+        ),
+        (
+            {
+                "distributed_tracing.sampler.full_granularity.enabled": True,
+                "distributed_tracing.sampler.partial_granularity.enabled": False,
+                "distributed_tracing.sampler.full_granularity._remote_parent_sampled": "default",
+                "distributed_tracing.sampler.full_granularity.remote_parent_sampled.adaptive.sampling_target": 5,
+                "distributed_tracing.sampler.full_granularity._remote_parent_not_sampled": "default",
+                "distributed_tracing.sampler.full_granularity.remote_parent_not_sampled.adaptive.sampling_target": 6,
+            },
+            {"traceparent": "00-0af7651916cd43dd8448eb211c80319c-00f067aa0ba902b7-01"},
+            (True, 1),
+            1,
+            1,
+            5,
+        ),
+        (
+            {
+                "distributed_tracing.sampler.full_granularity.enabled": True,
+                "distributed_tracing.sampler.partial_granularity.enabled": False,
+                "distributed_tracing.sampler.full_granularity._remote_parent_sampled": "default",
+                "distributed_tracing.sampler.full_granularity.remote_parent_sampled.adaptive.sampling_target": 5,
+                "distributed_tracing.sampler.full_granularity._remote_parent_not_sampled": "default",
+                "distributed_tracing.sampler.full_granularity.remote_parent_not_sampled.adaptive.sampling_target": 6,
+            },
+            {"traceparent": "00-0af7651916cd43dd8448eb211c80319c-00f067aa0ba902b7-00"},
+            (True, 2),
+            1,
+            1,
+            6,
+        ),
+    ),
+)
+def test_distributed_trace_uses_sampling_instance(
+    dt_settings,
+    dt_headers,
+    expected_sampling_instance_called,
+    expected_adaptive_computed_count,
+    expected_adaptive_sampled_count,
+    expected_adaptive_sampling_target,
+):
+    test_settings = _override_settings.copy()
+    test_settings.update(dt_settings)
+    function_called_decorator = validate_function_called(
+        "newrelic.core.samplers.adaptive_sampler", "AdaptiveSampler.compute_sampled"
+    )
+
+    @function_called_decorator
+    @override_application_settings(test_settings)
+    @background_task(name="test_distributed_trace_attributes")
+    def _test():
+        txn = current_transaction()
+        application = txn._application._agent._applications.get(txn.settings.app_name)
+        # Re-initialize sampler proxy after overriding settings.
+        application.sampler.__init__(txn.settings)
+
+        accept_distributed_trace_headers(dt_headers)
+        # Explicitly call this so we can assert sampling decision during the transaction
+        # as opposed to after it ends and we lose the application context.
+        txn._make_sampling_decision()
+
+        assert (
+            application.sampler._samplers[expected_sampling_instance_called].computed_count
+            == expected_adaptive_computed_count
+        )
+        assert (
+            application.sampler._samplers[expected_sampling_instance_called].sampled_count
+            == expected_adaptive_sampled_count
+        )
+        assert (
+            application.sampler._samplers[expected_sampling_instance_called].sampling_target
+            == expected_adaptive_sampling_target
+        )
+
+    _test()
diff --git a/tests/agent_unittests/test_distributed_tracing_settings.py b/tests/agent_unittests/test_distributed_tracing_settings.py
index 3668cfbe32..8b0402b47c 100644
--- a/tests/agent_unittests/test_distributed_tracing_settings.py
+++ b/tests/agent_unittests/test_distributed_tracing_settings.py
@@ -26,6 +26,46 @@
 distributed_tracing.exclude_newrelic_header = true
 """
 
+INI_FILE_FULL_GRAN_CONFLICTS = b"""
+[newrelic]
+distributed_tracing.sampler.remote_parent_sampled = default
+distributed_tracing.sampler.remote_parent_not_sampled = default
+distributed_tracing.sampler.full_granularity.remote_parent_sampled = always_on
+distributed_tracing.sampler.full_granularity.remote_parent_not_sampled = always_off
+"""
+
+INI_FILE_FULL_GRAN_CONFLICTS_ADAPTIVE = b"""
+[newrelic]
+distributed_tracing.sampler.remote_parent_sampled = always_on
+distributed_tracing.sampler.remote_parent_not_sampled = always_off
+distributed_tracing.sampler.full_granularity.remote_parent_sampled.adaptive.sampling_target = 10
+distributed_tracing.sampler.full_granularity.remote_parent_not_sampled.adaptive.sampling_target = 20
+"""
+
+INI_FILE_FULL_GRAN_MULTIPLE_SAMPLERS = b"""
+[newrelic]
+distributed_tracing.sampler.full_granularity.remote_parent_sampled.adaptive.sampling_target = 10
+distributed_tracing.sampler.full_granularity.remote_parent_not_sampled.adaptive.sampling_target = 20
+distributed_tracing.sampler.full_granularity.remote_parent_sampled.trace_id_ratio_based.sampling_target = 10
+distributed_tracing.sampler.full_granularity.remote_parent_not_sampled.trace_id_ratio_based.sampling_target = 20
+"""
+
+INI_FILE_PARTIAL_GRAN_CONFLICTS_ADAPTIVE = b"""
+[newrelic]
+distributed_tracing.sampler.partial_granularity.remote_parent_sampled = always_on
+distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled = always_off
+distributed_tracing.sampler.partial_granularity.remote_parent_sampled.adaptive.sampling_target = 10
+distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled.adaptive.sampling_target = 20
+"""
+
+INI_FILE_PARTIAL_GRAN_MULTIPLE_SAMPLERS = b"""
+[newrelic]
+distributed_tracing.sampler.partial_granularity.remote_parent_sampled.adaptive.sampling_target = 10
+distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled.adaptive.sampling_target = 20
+distributed_tracing.sampler.partial_granularity.remote_parent_sampled.trace_id_ratio_based.sampling_target = 10
+distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled.trace_id_ratio_based.sampling_target = 20
+"""
+
 
 # Tests for loading settings and testing for values precedence
 @pytest.mark.parametrize("ini,env,expected_format", ((INI_FILE_EMPTY, {}, False), (INI_FILE_W3C, {}, True)))
@@ -35,9 +75,33 @@ def test_distributed_trace_setings(ini, env, expected_format, global_settings):
 
 
 @pytest.mark.parametrize(
-    "ini,env",
+    "ini,env,expected",
     (
-        (
+        (  # Defaults to adaptive (default) sampler.
+            INI_FILE_EMPTY,
+            {},
+            ("default", "default", None, None),
+        ),
+        (  # More specific full granularity path overrides less specific path in ini file.
+            INI_FILE_FULL_GRAN_CONFLICTS,
+            {},
+            ("always_on", "always_off", None, None),
+        ),
+        (  # More specific sampler path overrides less specific path in ini file.
+            INI_FILE_FULL_GRAN_CONFLICTS_ADAPTIVE,
+            {},
+            ("adaptive", "adaptive", 10, 20),
+        ),
+        (  # ini file configuration takes precedence over env vars.
+            INI_FILE_FULL_GRAN_CONFLICTS_ADAPTIVE,
+            {
+                "NEW_RELIC_ENABLED": "true",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_SAMPLED_ADAPTIVE_SAMPLING_TARGET": "50",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED_ADAPTIVE_SAMPLING_TARGET": "30",
+            },
+            ("adaptive", "adaptive", 10, 20),
+        ),
+        (  # More specific full granularity path overrides less specific path in env vars.
             INI_FILE_EMPTY,
             {
                 "NEW_RELIC_ENABLED": "true",
@@ -46,21 +110,115 @@ def test_distributed_trace_setings(ini, env, expected_format, global_settings):
                 "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_SAMPLED": "always_on",
                 "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED": "always_off",
             },
+            ("always_on", "always_off", None, None),
+        ),
+        (  # Simple configuration works.
+            INI_FILE_EMPTY,
+            {
+                "NEW_RELIC_ENABLED": "true",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_REMOTE_PARENT_SAMPLED": "always_on",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_REMOTE_PARENT_NOT_SAMPLED": "always_off",
+            },
+            ("always_on", "always_off", None, None),
         ),
-        (
+        (  # More specific sampler path overrides less specific path in env vars.
             INI_FILE_EMPTY,
             {
                 "NEW_RELIC_ENABLED": "true",
                 "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_REMOTE_PARENT_SAMPLED": "always_on",
                 "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_REMOTE_PARENT_NOT_SAMPLED": "always_off",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_SAMPLED_ADAPTIVE_SAMPLING_TARGET": "20",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_FULL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED_ADAPTIVE_SAMPLING_TARGET": "20",
             },
+            ("adaptive", "adaptive", 20, 20),
+        ),
+        (  # Ignores other unknown samplers.
+            INI_FILE_FULL_GRAN_MULTIPLE_SAMPLERS,
+            {},
+            ("adaptive", "adaptive", 10, 20),
+        ),
+    ),
+)
+def test_full_granularity_precedence(ini, env, global_settings, expected):
+    settings = global_settings()
+
+    app_settings = finalize_application_settings(settings=settings)
+
+    assert app_settings.distributed_tracing.sampler.full_granularity._remote_parent_sampled == expected[0]
+    assert app_settings.distributed_tracing.sampler.full_granularity._remote_parent_not_sampled == expected[1]
+    assert (
+        app_settings.distributed_tracing.sampler.full_granularity.remote_parent_sampled.adaptive.sampling_target
+        == expected[2]
+    )
+    assert (
+        app_settings.distributed_tracing.sampler.full_granularity.remote_parent_not_sampled.adaptive.sampling_target
+        == expected[3]
+    )
+
+
+@pytest.mark.parametrize(
+    "ini,env,expected",
+    (
+        (  # Defaults to adaptive (default) sampler.
+            INI_FILE_EMPTY,
+            {},
+            ("default", "default", None, None),
+        ),
+        (  # More specific sampler path overrides less specific path in ini file.
+            INI_FILE_PARTIAL_GRAN_CONFLICTS_ADAPTIVE,
+            {},
+            ("adaptive", "adaptive", 10, 20),
+        ),
+        (  # ini config takes precedence over env vars.
+            INI_FILE_PARTIAL_GRAN_CONFLICTS_ADAPTIVE,
+            {
+                "NEW_RELIC_ENABLED": "true",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_SAMPLED": "always_on",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED": "always_off",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_SAMPLED_ADAPTIVE_SAMPLING_TARGET": "20",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED_ADAPTIVE_SAMPLING_TARGET": "30",
+            },
+            ("adaptive", "adaptive", 10, 20),
+        ),
+        (  # Simple configuration works.
+            INI_FILE_EMPTY,
+            {
+                "NEW_RELIC_ENABLED": "true",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_SAMPLED": "always_on",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED": "always_off",
+            },
+            ("always_on", "always_off", None, None),
+        ),
+        (  # More specific sampler path overrides less specific path in env vars.
+            INI_FILE_EMPTY,
+            {
+                "NEW_RELIC_ENABLED": "true",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_SAMPLED": "always_on",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED": "always_off",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_SAMPLED_ADAPTIVE_SAMPLING_TARGET": "10",
+                "NEW_RELIC_DISTRIBUTED_TRACING_SAMPLER_PARTIAL_GRANULARITY_REMOTE_PARENT_NOT_SAMPLED_ADAPTIVE_SAMPLING_TARGET": "20",
+            },
+            ("adaptive", "adaptive", 10, 20),
+        ),
+        (  # Ignores other unknown samplers.
+            INI_FILE_PARTIAL_GRAN_MULTIPLE_SAMPLERS,
+            {},
+            ("adaptive", "adaptive", 10, 20),
         ),
     ),
 )
-def test_full_granularity_precedence(ini, env, global_settings):
+def test_partial_granularity_precedence(ini, env, global_settings, expected):
     settings = global_settings()
 
     app_settings = finalize_application_settings(settings=settings)
 
-    assert app_settings.distributed_tracing.sampler.full_granularity.remote_parent_sampled == "always_on"
-    assert app_settings.distributed_tracing.sampler.full_granularity.remote_parent_not_sampled == "always_off"
+    assert app_settings.distributed_tracing.sampler.partial_granularity._remote_parent_sampled == expected[0]
+    assert app_settings.distributed_tracing.sampler.partial_granularity._remote_parent_not_sampled == expected[1]
+    assert (
+        app_settings.distributed_tracing.sampler.partial_granularity.remote_parent_sampled.adaptive.sampling_target
+        == expected[2]
+    )
+    assert (
+        app_settings.distributed_tracing.sampler.partial_granularity.remote_parent_not_sampled.adaptive.sampling_target
+        == expected[3]
+    )
diff --git a/tests/coroutines_asyncio/test_context_propagation.py b/tests/coroutines_asyncio/test_context_propagation.py
index b338b6ec3e..eb5c358745 100644
--- a/tests/coroutines_asyncio/test_context_propagation.py
+++ b/tests/coroutines_asyncio/test_context_propagation.py
@@ -36,16 +36,31 @@
     import uvloop
 
     loop_policies = (pytest.param(None, id="asyncio"), pytest.param(uvloop.EventLoopPolicy(), id="uvloop"))
+    uvloop_factory = (pytest.param(uvloop.new_event_loop, id="uvloop"), pytest.param(None, id="None"))
 except ImportError:
     loop_policies = (pytest.param(None, id="asyncio"),)
+    uvloop_factory = (pytest.param(None, id="None"),)
+
+
+def loop_factories():
+    import asyncio
+
+    if sys.platform == "win32":
+        return (pytest.param(asyncio.ProactorEventLoop, id="asyncio.ProactorEventLoop"), *uvloop_factory)
+    else:
+        return (pytest.param(asyncio.SelectorEventLoop, id="asyncio.SelectorEventLoop"), *uvloop_factory)
 
 
 @pytest.fixture(autouse=True)
 def reset_event_loop():
-    from asyncio import set_event_loop, set_event_loop_policy
+    try:
+        from asyncio import set_event_loop, set_event_loop_policy
+
+        # Remove the loop policy to avoid side effects
+        set_event_loop_policy(None)
+    except ImportError:
+        from asyncio import set_event_loop
 
-    # Remove the loop policy to avoid side effects
-    set_event_loop_policy(None)
     set_event_loop(None)
 
 
@@ -102,6 +117,7 @@ async def _test(asyncio, schedule, nr_enabled=True):
     return trace
 
 
+@pytest.mark.skipif(sys.version_info >= (3, 16), reason="loop_policy is not available")
 @pytest.mark.parametrize("loop_policy", loop_policies)
 @pytest.mark.parametrize("schedule", ("create_task", "ensure_future"))
 @validate_transaction_metrics(
@@ -166,10 +182,12 @@ def handle_exception(loop, context):
         memcache_trace("cmd"),
     ],
 )
-def test_two_transactions(event_loop, trace):
+def test_two_transactions_with_global_event_loop(event_loop, trace):
     """
     Instantiate a coroutine in one transaction and await it in
     another. This should not cause any errors.
+    This uses the global event loop policy, which has been deprecated
+    since Python 3.11 and is scheduled for removal in Python 3.16.
     """
     import asyncio
 
@@ -211,6 +229,99 @@ async def await_task():
     event_loop.run_until_complete(asyncio.gather(afut, bfut))
 
 
+@pytest.mark.skipif(sys.version_info < (3, 11), reason="asyncio.Runner is not available")
+@validate_transaction_metrics("await_task", background_task=True)
+@validate_transaction_metrics("create_coro", background_task=True, index=-2)
+@pytest.mark.parametrize("loop_factory", loop_factories())
+@pytest.mark.parametrize(
+    "trace",
+    [
+        function_trace(name="simple_gen"),
+        external_trace(library="lib", url="http://foo.com"),
+        database_trace("select * from foo"),
+        datastore_trace("lib", "foo", "bar"),
+        message_trace("lib", "op", "typ", "name"),
+        memcache_trace("cmd"),
+    ],
+)
+def test_two_transactions_with_loop_factory(trace, loop_factory):
+    """
+    Instantiate a coroutine in one transaction and await it in
+    another. This should not cause any errors.
+    Starting in Python 3.11, the asyncio.Runner class was added
+    as well as the loop_factory parameter.  The loop_factory
+    parameter provides a replacement for loop policies (which
+    are scheduled for removal in Python 3.16).
+    """
+    import asyncio
+
+    @trace
+    async def task():
+        pass
+
+    @background_task(name="create_coro")
+    async def create_coro():
+        return asyncio.create_task(task())
+
+    @background_task(name="await_task")
+    async def await_task(task_to_await):
+        return await task_to_await
+
+    async def _main():
+        _task = await create_coro()
+        return await await_task(_task)
+
+    with asyncio.Runner(loop_factory=loop_factory) as runner:
+        runner.run(_main())
+
+
+@pytest.mark.skipif(sys.version_info < (3, 11), reason="loop_factory/asyncio.Runner is not available")
+@pytest.mark.parametrize("loop_factory", loop_factories())
+@validate_transaction_metrics(
+    "test_context_propagation:test_context_propagation_with_loop_factory",
+    background_task=True,
+    scoped_metrics=(("Function/waiter2", 2), ("Function/waiter3", 2)),
+)
+@background_task()
+def test_context_propagation_with_loop_factory(loop_factory):
+    import asyncio
+
+    exceptions = []
+
+    def handle_exception(loop, context):
+        exceptions.append(context)
+
+        # Call default handler for standard logging
+        loop.default_exception_handler(context)
+
+    async def subtask():
+        with FunctionTrace(name="waiter2", terminal=True):
+            pass
+
+        await child()
+
+    async def _task(trace):
+        assert current_trace() == trace
+
+        await subtask()
+
+    trace = current_trace()
+
+    with asyncio.Runner(loop_factory=loop_factory) as runner:
+        assert trace == current_trace()
+        runner._loop.set_exception_handler(handle_exception)
+        runner.run(_task(trace))
+        runner.run(_task(trace))
+
+    # The agent should have removed all traces from the cache since
+    # run_until_complete has terminated (all callbacks scheduled inside the
+    # task have run)
+    assert len(trace_cache()) == 1  # Sentinel is all that remains
+
+    # # Assert that no exceptions have occurred
+    assert not exceptions, exceptions
+
+
 # Sentinel left in cache transaction exited
 async def sentinel_in_cache_txn_exited(asyncio, bg):
     event = asyncio.Event()
diff --git a/tests/testing_support/asgi_testing.py b/tests/testing_support/asgi_testing.py
index 821a20fe96..5c97be8860 100644
--- a/tests/testing_support/asgi_testing.py
+++ b/tests/testing_support/asgi_testing.py
@@ -106,7 +106,7 @@ def process_output(self):
             if self.response_state is ResponseState.NOT_STARTED:
                 assert message["type"] == "http.response.start"
                 response_status = message["status"]
-                response_headers = message.get("headers", response_headers)
+                response_headers = list(message.get("headers", response_headers))
                 self.response_state = ResponseState.BODY
             elif self.response_state is ResponseState.BODY:
                 assert message["type"] == "http.response.body"
diff --git a/tests/testing_support/sample_asgi_applications.py b/tests/testing_support/sample_asgi_applications.py
index c1ef860763..e281a7cbf2 100644
--- a/tests/testing_support/sample_asgi_applications.py
+++ b/tests/testing_support/sample_asgi_applications.py
@@ -114,6 +114,23 @@ async def normal_asgi_application(scope, receive, send):
     await send({"type": "http.response.body", "body": output})
 
 
+@ASGIApplicationWrapper
+async def asgi_application_generator_headers(scope, receive, send):
+    if scope["type"] == "lifespan":
+        return await handle_lifespan(scope, receive, send)
+
+    if scope["type"] != "http":
+        raise ValueError("unsupported")
+
+    def headers():
+        yield (b"x-my-header", b"myvalue")
+
+    await send({"type": "http.response.start", "status": 200, "headers": headers()})
+    await send({"type": "http.response.body"})
+
+    assert current_transaction() is None
+
+
 async def handle_lifespan(scope, receive, send):
     """Handle lifespan protocol with no-ops to allow more compatibility."""
     while True:
diff --git a/tox.ini b/tox.ini
index 39148b657f..98cea6ee29 100644
--- a/tox.ini
+++ b/tox.ini
@@ -113,11 +113,11 @@ envlist =
     python-adapter_gunicorn-{py38,py39,py310,py311,py312,py313}-aiohttp03-gunicornlatest,
     ;; Package not ready for Python 3.14 (aiohttp's worker not updated)
     ; python-adapter_gunicorn-py314-aiohttp03-gunicornlatest,
-    python-adapter_hypercorn-{py38,py39,py310,py311,py312,py313,py314}-hypercornlatest,
-    python-adapter_hypercorn-py38-hypercorn{0010,0011,0012,0013},
+    python-adapter_hypercorn-{py310,py311,py312,py313,py314}-hypercornlatest,
+    python-adapter_hypercorn-{py38,py39}-hypercorn{0010,0011,0012,0013},
     python-adapter_mcp-{py310,py311,py312,py313,py314},
-    python-adapter_uvicorn-{py38,py39,py310,py311,py312,py313,py314}-uvicornlatest,
-    python-adapter_uvicorn-py38-uvicorn014,
+    python-adapter_uvicorn-{py39,py310,py311,py312,py313,py314}-uvicornlatest,
+    python-adapter_uvicorn-py38-uvicorn020,
     python-adapter_waitress-{py38,py39,py310,py311,py312,py313,py314}-waitresslatest,
     python-application_celery-{py38,py39,py310,py311,py312,py313,py314,pypy311}-celerylatest,
     python-application_celery-py311-celery{0504,0503,0502},
@@ -176,7 +176,8 @@ envlist =
     python-framework_strawberry-{py38,py39,py310,py311,py312}-strawberry02352,
     python-framework_strawberry-{py38,py39,py310,py311,py312,py313,py314}-strawberrylatest,
     python-framework_tornado-{py38,py39,py310,py311,py312,py313,py314}-tornadolatest,
-    python-framework_tornado-{py310,py311,py312,py313,py314}-tornadomaster,
+    ; Remove `python-framework_tornado-py314-tornadomaster` temporarily
+    python-framework_tornado-{py310,py311,py312,py313}-tornadomaster,
     python-logger_logging-{py38,py39,py310,py311,py312,py313,py314,pypy311},
     python-logger_loguru-{py38,py39,py310,py311,py312,py313,py314,pypy311}-logurulatest,
     python-logger_structlog-{py38,py39,py310,py311,py312,py313,py314,pypy311}-structloglatest,
@@ -231,16 +232,18 @@ deps =
     adapter_gunicorn-aiohttp03: aiohttp<4.0
     adapter_gunicorn-gunicorn19: gunicorn<20
     adapter_gunicorn-gunicornlatest: gunicorn
-    adapter_hypercorn-hypercornlatest: hypercorn[h3]
+    adapter_hypercorn-hypercornlatest: hypercorn[h3]!=0.18
     adapter_hypercorn-hypercorn0013: hypercorn[h3]<0.14
     adapter_hypercorn-hypercorn0012: hypercorn[h3]<0.13
     adapter_hypercorn-hypercorn0011: hypercorn[h3]<0.12
     adapter_hypercorn-hypercorn0010: hypercorn[h3]<0.11
     adapter_hypercorn: niquests
     adapter_mcp: fastmcp
-    adapter_uvicorn-uvicorn014: uvicorn<0.15
+    adapter_uvicorn-uvicorn020: uvicorn<0.21
+    adapter_uvicorn-uvicorn020: uvloop<0.20
     adapter_uvicorn-uvicornlatest: uvicorn
     adapter_uvicorn: typing-extensions
+    adapter_uvicorn: uvloop
     adapter_waitress: WSGIProxy2
     adapter_waitress-waitresslatest: waitress
     agent_features: beautifulsoup4